The development of a potentially life-threatening serotonin syndrome or neuroleptic malignant syndrome nms -like reactions have been reported with antidepressants alone and may occur with trazodone treatment, but particularly with concomitant use of other serotoninergic drugs including ssris, snris and triptans and with drugs that impair metabolism of serotonin including monoamine oxidase inhibitors maois , or with antipsychotics or other dopamine antagonists.
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