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SkinAlopeciaerythema nodosumhyperpigmentation of nailspruritustoxic epidermal necrolysisand vasculitisMaculopapular and erythematous rashesExfoliative dermatitis has been reportedFixed drug eruptionsincluding balanitishave been reportedErythema multiforme and Stevens-Johnson syndrome have been reportedPhotosensitivity is discussed aboveSee WARNINGSPigmentation of the skin and mucous membranes has been reported.

The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.

The anti-anabolic action of the tetracyclines may cause an increase in BUNWhile this is not a problem in those with normal renal functionin patients with significantly impaired functionhigher serum levels of tetracycline may lead to azotemiahyperphosphatemiaand acidosisUnder such conditionsmonitoring of creatinine and BUN is recommendedand the total daily dosage should not exceed 200 mg in 24 hoursIf renal impairment existseven usual oral or parenteral doses may lead to systemic accumulation of the drug and possible liver toxicity.

Although no controlled clinical efficacy studies have been conductedlimited clinical data show that oral minocycline hydrochloride has been used successfully in the treatment of infections caused by Mycobacterium marinum

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patients who experience these symptoms should be cautioned about driving vehicles or using hazardous machinery while on minocin therapy.

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